The game, developed by Beenox on all platforms except the Nintendo DS which was developed by Amaze Entertainment, allows users to play through scenes from the movie as Ginormica, B.O.B., and The Missing Link, and features drop-in/out co-op. Players can play as Dr. Cockroach, Ph.D in multiplayer co-op, as well as Insectosaurus on the Nintendo DS version of the game. The music was composed by Jim Dooley, with live brass recorded at the Warner Brothers Eastwood Scoring Stage.
- Kiefer Sutherland doesn't reprise his role.
- Hugh Laurie doesn't reprise his role either.
- Derek Dietl is absent.
- President Hathaway is absent.
- Carl Murphy is absent.
- Wendy Murphy is absent.
- A prologue scene where the monsters attempt to escape is added.
- Another scene is added to include the alien scorpion robot.
The game received mixed to positive reviews from critics. The PlayStation 2 version of the game received a 64/100 from Metacritic, and the Xbox 360 received 63/100. All platforms scored 5/10 at IGN, with an exception for the Nintendo DS version, which scored a 3/10.